Multivariate Meta-Analysis of Genetic Association Studies: A Simulation Study
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چکیده
منابع مشابه
Multivariate Meta-Analysis of Genetic Association Studies: A Simulation Study
In a meta-analysis with multiple end points of interests that are correlated between or within studies, multivariate approach to meta-analysis has a potential to produce more precise estimates of effects by exploiting the correlation structure between end points. However, under random-effects assumption the multivariate estimation is more complex (as it involves estimation of more parameters si...
متن کاملCorrection: Multivariate Meta-Analysis of Genetic Association Studies: A Simulation Study
to correct errors in equations and formatting that were introduced during the typesetting process. The publisher apologizes for the errors. Please download this article again to view the correct version. The originally published, uncor-rected article and the republished, corrected article are provided here for reference. open access article distributed under the terms of the Creative Commons At...
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Meta-analysis, a statistical tool for combining results across studies, is becoming popular as a method for resolving discrepancies in genetic association studies. Persistent difficulties in obtaining robust, replicable results in genetic association studies are almost certainly because genetic effects are small, requiring studies with many thousands of subjects to be detected. In this article,...
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Population stratification: occurs when a population consists of a set of subpopulations. If one subpopulation contains a frequency of disease allele that is relatively high, then any marker also at a higher frequency will appear to be associated, wherever it is located in the genome. Transmission disequilibrium test: a method of detecting genetic association that avoids problems of population s...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0133243